Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics

The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations across multiple cancer types including both solid and hematologic malignancies has revolutionized our understanding of oncogenesis in these malignancies and the potential for targeted therapeutics using small mole...

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Foilsithe in:Front Oncol
Main Authors: Golub, Danielle, Iyengar, Nishanth, Dogra, Siddhant, Wong, Taylor, Bready, Devin, Tang, Karen, Modrek, Aram S., Placantonakis, Dimitris G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534082/
https://ncbi.nlm.nih.gov/pubmed/31165048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00417
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