Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma

PURPOSE: Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct glioma molecular subtype for which no effective molecularly-directed therapy exists. Low-grade gliomas, which are 80–90% IDH mutant, have high RNA levels of the cell surface Notch ligand DLL3. We sought to determine DLL3 expressio...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Spino, Marissa, Kurz, Sylvia C., Chiriboga, Luis, Serrano, Jonathan, Zeck, Briana, Sen, Namita, Patel, Seema, Shen, Guomiao, Vasudevaraja, Varshini, Suryadevara, Carter M., Frenster, Joshua, Tateishi, Kensuke, Wakimoto, Hiroaki, Jain, Rajan, Riina, Howard A., Nicolaides, Theodore P., Sulman, Erik P., Cahill, Daniel P., Golfinos, John G., Isse, Kumiko, Saunders, Laura R., Zagzag, David, Placantonakis, Dimitris, Snuderl, Matija, Chi, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365589/
https://ncbi.nlm.nih.gov/pubmed/30397180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2312
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