Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. Here, we report a microfluidics-based, patient-specific ‘GBM-on-a-Chip’ microphysiological sys...

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Udgivet i:eLife
Main Authors: Cui, Xin, Ma, Chao, Vasudevaraja, Varshini, Serrano, Jonathan, Tong, Jie, Peng, Yansong, Delorenzo, Michael, Shen, Guomiao, Frenster, Joshua, Morales, Renee-Tyler Tan, Qian, Weiyi, Tsirigos, Aristotelis, Chi, Andrew S, Jain, Rajan, Kurz, Sylvia C, Sulman, Erik P, Placantonakis, Dimitris G, Snuderl, Matija, Chen, Weiqiang
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556869/
https://ncbi.nlm.nih.gov/pubmed/32909947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52253
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