Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma

PURPOSE: Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct glioma molecular subtype for which no effective molecularly-directed therapy exists. Low-grade gliomas, which are 80–90% IDH mutant, have high RNA levels of the cell surface Notch ligand DLL3. We sought to determine DLL3 expressio...

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Published in:Clin Cancer Res
Main Authors: Spino, Marissa, Kurz, Sylvia C., Chiriboga, Luis, Serrano, Jonathan, Zeck, Briana, Sen, Namita, Patel, Seema, Shen, Guomiao, Vasudevaraja, Varshini, Suryadevara, Carter M., Frenster, Joshua, Tateishi, Kensuke, Wakimoto, Hiroaki, Jain, Rajan, Riina, Howard A., Nicolaides, Theodore P., Sulman, Erik P., Cahill, Daniel P., Golfinos, John G., Isse, Kumiko, Saunders, Laura R., Zagzag, David, Placantonakis, Dimitris, Snuderl, Matija, Chi, Andrew S.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365589/
https://ncbi.nlm.nih.gov/pubmed/30397180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2312
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