Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases

Aberrant activation of the signal transducer and activator of transcription 3 (STAT3) and the nuclear factor‐κB (NF‐κB) signalling pathways is associated with the development of cancer and inflammatory diseases. JAKs and IKKs are the key regulators in the STAT3 and NF‐κB signalling respectively. The...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Liu, Man, Xiao, Cheng‐qian, Sun, Ming‐wei, Tan, Min‐jia, Hu, Li‐hong, Yu, Qiang
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533482/
https://ncbi.nlm.nih.gov/pubmed/30993883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14322
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