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Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases

Aberrant activation of the signal transducer and activator of transcription 3 (STAT3) and the nuclear factor‐κB (NF‐κB) signalling pathways is associated with the development of cancer and inflammatory diseases. JAKs and IKKs are the key regulators in the STAT3 and NF‐κB signalling respectively. The...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Mol Med
Prif Awduron: Liu, Man, Xiao, Cheng‐qian, Sun, Ming‐wei, Tan, Min‐jia, Hu, Li‐hong, Yu, Qiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533482/
https://ncbi.nlm.nih.gov/pubmed/30993883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14322
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