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Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
Aberrant activation of the signal transducer and activator of transcription 3 (STAT3) and the nuclear factor‐κB (NF‐κB) signalling pathways is associated with the development of cancer and inflammatory diseases. JAKs and IKKs are the key regulators in the STAT3 and NF‐κB signalling respectively. The...
Gespeichert in:
| Veröffentlicht in: | J Cell Mol Med |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533482/ https://ncbi.nlm.nih.gov/pubmed/30993883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14322 |
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