Modeling HIV-1 Latency Using Primary CD4(+) T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy

The low frequency of latently HIV-infected cells in vivo limits the testing of potential HIV cure strategies using cells from successfully suppressed individuals. To date, primary cell models of latency use cells infected in vitro. Primary CD4(+) T cell models carrying an individual’s endogenous HIV...

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Bibliographic Details
Published in:J Virol
Main Authors: Takata, Hiroshi, Kessing, Cari, Sy, Aaron, Lima, Noemia, Sciumbata, Julia, Mori, Luisa, Jones, R. Brad, Chomont, Nicolas, Michael, Nelson L., Valente, Susana, Trautmann, Lydie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532074/
https://ncbi.nlm.nih.gov/pubmed/30918072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02248-18
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