In vivo suppression of HIV rebound by didehydro-Cortistatin A, a “block-and-lock” strategy for HIV-1 cure

HIV-1 Tat activates viral transcription and limited Tat-transactivation correlates with latency establishment. We postulated a “block-and-lock” functional cure approach based on properties of the Tat-inhibitor didehydro-Cortistatin A (dCA). HIV-1 transcriptional inhibitors could block ongoing viremi...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kessing, Cari F., Nixon, Christopher C., Li, Chuan, Tsai, Perry M., Takata, Hiroshi, Mousseau, Guillaume, Ho, Phong T., Honeycutt, Jenna B., Fallahi, Mohammad, Trautmann, Lydie, Garcia, J. Victor, Valente, Susana T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653276/
https://ncbi.nlm.nih.gov/pubmed/29045830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.080
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