Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity

Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson’s disease (PD). Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial protei...

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Veröffentlicht in:Acta Neuropathol
Hauptverfasser: Hu, Di, Sun, Xiaoyan, Liao, Xudong, Zhang, Xinwen, Zarabi, Sara, Schimmer, Aaron, Hong, Yuning, Ford, Christopher, Luo, Yu, Qi, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2019
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531426/
https://ncbi.nlm.nih.gov/pubmed/30877431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01993-2
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