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Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy

Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease participates in mitochondrial protein quality control by degrading misfolded or damaged proteins, thus maintaining normal metabolic function. Mitochondrial ClpP is a stable heptamer ring with peptidase activit...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Nouri, Kazem, Feng, Yue, Schimmer, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547079/
https://ncbi.nlm.nih.gov/pubmed/33037181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03062-z
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