Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity

Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson’s disease (PD). Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial protei...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Neuropathol
Main Authors: Hu, Di, Sun, Xiaoyan, Liao, Xudong, Zhang, Xinwen, Zarabi, Sara, Schimmer, Aaron, Hong, Yuning, Ford, Christopher, Luo, Yu, Qi, Xin
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2019
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531426/
https://ncbi.nlm.nih.gov/pubmed/30877431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01993-2
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