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Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A(2A) Receptor
Agonist binding in the extracellular region of the G protein-coupled adenosine A2A receptor increases its affinity to the G proteins in the intracellular region, and vice versa. The structural basis for this effect is not evident from the crystal structures of A(2A)R in various conformational states...
Sparad:
| I publikationen: | Structure |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Cell Press
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6531377/ https://ncbi.nlm.nih.gov/pubmed/30713025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.12.007 |
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