Adaptive plasticity of IL-10(+) and IL-35(+) T(reg) cells cooperatively promotes tumor T cell exhaustion

Regulatory T cells (T(reg) cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. T(reg) cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expression on tumor-infiltrating lymphocytes (TILs); however, the underlying mediators and m...

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Publicado no:Nat Immunol
Main Authors: Sawant, Deepali V., Yano, Hiroshi, Chikina, Maria, Zhang, Qianxia, Liao, Mengting, Liu, Chang, Callahan, Derrick J, Sun, Zhe, Sun, Tao, Tabib, Tracy, Pennathur, Arjun, Corry, David B., Luketich, James D., Lafyatis, Robert, Chen, Wei, Poholek, Amanda C., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531353/
https://ncbi.nlm.nih.gov/pubmed/30936494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0346-9
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