Interferon-γ drives T(reg) fragility to promote anti-tumor immunity

Regulatory T cells (T(regs)) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral T(reg) stability and function but is dispensable for peripheral immune tolerance. T(reg)-restricted Nrp1 deletion results in profound tumor resistance due to T(reg) functional...

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Published in:Cell
Main Authors: Overacre-Delgoffe, Abigail E, Chikina, Maria, Dadey, Rebekah E, Yano, Hiroshi, Brunazzi, Erin A, Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M, Kolls, Jay K, Sander, Cindy, Shuai, Yongli, Normolle, Daniel P, Kirkwood, John M, Ferris, Robert L, Delgoffe, Greg M, Bruno, Tullia C, Workman, Creg J, Vignali, Dario AA
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509332/
https://ncbi.nlm.nih.gov/pubmed/28552348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.05.005
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