Interferon-γ drives T(reg) fragility to promote anti-tumor immunity

Regulatory T cells (T(regs)) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral T(reg) stability and function but is dispensable for peripheral immune tolerance. T(reg)-restricted Nrp1 deletion results in profound tumor resistance due to T(reg) functional...

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Veröffentlicht in:Cell
Hauptverfasser: Overacre-Delgoffe, Abigail E, Chikina, Maria, Dadey, Rebekah E, Yano, Hiroshi, Brunazzi, Erin A, Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M, Kolls, Jay K, Sander, Cindy, Shuai, Yongli, Normolle, Daniel P, Kirkwood, John M, Ferris, Robert L, Delgoffe, Greg M, Bruno, Tullia C, Workman, Creg J, Vignali, Dario AA
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509332/
https://ncbi.nlm.nih.gov/pubmed/28552348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.05.005
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