Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance

Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms that IL-35 assume and its role in peripheral tolerance remain elusive. We induce CBA-specific, IL-35-producing T regulatory (Treg) cells in T...

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Pubblicato in:Cell Rep
Autori principali: Sullivan, Jeremy A., Tomita, Yusuke, Jankowska-Gan, Ewa, Lema, Diego A., Arvedson, Matt P., Nair, Ashita, Bracamonte-Baran, William, Zhou, Ying, Meyer, Kristy K., Zhong, Weixiong, Sawant, Deepali V., Szymczak-Workman, Andrea L., Zhang, Qianxia, Workman, Creg J., Hong, Seungpyo, Vignali, Dario A.A., Burlingham, William J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042971/
https://ncbi.nlm.nih.gov/pubmed/31995748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.081
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