Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

Current treatments for Mycobacterium tuberculosis infections require long and complicated regimens that can lead to patient non-compliance, increasing incidences of antibiotic-resistant strains, and lack of efficacy against latent stages of disease. Thus, new therapeutics are needed to improve tuber...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Washburn, Alex, Abdeen, Sanofar, Ovechkina, Yulia, Ray, Anne-Marie, Stevens, Mckayla, Chitre, Siddhi, Sivinski, Jared, Park, Yangshin, Johnson, James, Hoang, Quyen Q., Chapman, Eli, Parish, Tanya, Johnson, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531345/
https://ncbi.nlm.nih.gov/pubmed/31047750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.04.034
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