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Two-Pore Physiologically Based Pharmacokinetic Model with De Novo Derived Parameters for Predicting Plasma PK of Different Size Protein Therapeutics
Two-pore PBPK models have been used for characterizing the PK of protein therapeutics since 1990s. However, widespread utilization of these models is hampered by the lack of a priori parameter values, which are typically estimated using the observed data. To overcome this hurdle, here we have presen...
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| Publicado no: | J Pharmacokinet Pharmacodyn |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6531344/ https://ncbi.nlm.nih.gov/pubmed/31028591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-019-09639-2 |
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