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Effect of Size on Solid Tumor Disposition of Protein Therapeutics
In this study, we evaluated the effect of size on tumor disposition of protein therapeutics, including the plasma and tumor pharmacokinetics (PK) of trastuzumab (∼150 kDa), FcRn-nonbinding trastuzumab (∼150 kDa), F(ab)(2) fragment of trastuzumab (∼100 kDa), Fab fragment of trastuzumab (∼50 kDa), and...
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| Udgivet i: | Drug Metab Dispos |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6756290/ https://ncbi.nlm.nih.gov/pubmed/31387870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.087809 |
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