Pitfalls of Using Numerical Predictive Checks for Population Physiologically Based Pharmacokinetic Model Evaluation

Comparisons between observed data and model simulations represent a critical component for establishing confidence in population physiologically-based pharmacokinetic (Pop-PBPK) models. Numerical predictive checks (NPC) that assess the proportion of observed data that correspond to Pop-PBPK model pr...

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Bibliographic Details
Published in:J Pharmacokinet Pharmacodyn
Main Authors: Maharaj, Anil R., Wu, Huali, Hornik, Christoph P., Cohen-Wolkowiez, Michael
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531337/
https://ncbi.nlm.nih.gov/pubmed/31016557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-019-09636-5
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