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Physiologically Based Pharmacokinetic Modeling for Trimethoprim (TMP) and Sulfamethoxazole (SMP) in Children
OBJECTIVE: We aimed to 1) determine whether opportunistically collected data can be used to develop physiologically based pharmacokinetic (PBPK) models in pediatric patients, and 2) to characterize age-related maturational changes in drug disposition for the renally eliminated and hepatically metabo...
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| 發表在: | Clin Pharmacokinet |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6586496/ https://ncbi.nlm.nih.gov/pubmed/30840200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-00733-1 |
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