Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity

Most tissue-resident macrophage populations develop during embryogenesis, self-renew in the steady-state and expand during type 2 immunity. Whether shared mechanisms regulate the proliferation of macrophages in homeostasis and disease is unclear. Here we found that the transcription factor Bhlhe40 w...

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Publicado no:Nat Immunol
Main Authors: Jarjour, Nicholas N., Schwarzkopf, Elizabeth A., Bradstreet, Tara R., Shchukina, Irina, Lin, Chih-Chung, Huang, Stanley Ching-Cheng, Lai, Chin-Wen, Cook, Melissa E., Taneja, Reshma, Stappenbeck, Thaddeus S., Randolph, Gwendalyn J., Artyomov, Maxim N., Urban, Joseph F., Edelson, Brian T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531324/
https://ncbi.nlm.nih.gov/pubmed/31061528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0382-5
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