Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion.

Mast cell (MC) mediator release following crosslinking of surface-bound IgE antibody by ingested antigen underlies food allergy. However, IgE antibodies are not uniformly associated with food allergy, and intestinal MC load is an important determinant. Atopic dermatitis (AD), characterized by prurit...

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Pubblicato in:Immunity
Autori principali: Leyva-Castillo, Juan-Manuel, Galand, Claire, Kam, Christy, Burton, Oliver, Gurish, Michael, Musser, Melissa A., Goldsmith, Jeffrey D., Hait, Elizabeth, Nurko, Samuel, Brombacher, Frank, Dong, Chen, Finkelman, Fred D., Lee, Richard T., Ziegler, Steven, Chiu, Isaac, Austen, K. Frank, Geha, Raif S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531322/
https://ncbi.nlm.nih.gov/pubmed/31027995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.03.023
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