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Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (αKG), NAD(P)H, and CO(2). IDHs epigenetically control gene expression through effects on αKG-dependent dioxygenases, maintain redox balance and promote anaple...
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| Publicado en: | Sci Adv |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Association for the Advancement of Science
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6530995/ https://ncbi.nlm.nih.gov/pubmed/31131326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw4543 |
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