Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing

AIMS: The role of uncoupling protein 2 (UCP2) in cardiac adaptation to pressure overload remains unclear. In a classical model of left ventricular pressure overload genetic deletion of UCP2 (UCP2(−/−)) protected against cardiac hypertrophy and failure. However, in UCP2(−/−) mice increased proliferat...

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Publié dans:Cardiovasc Res
Auteurs principaux: Esfandiary, Azadeh, Kutsche, Hanna S, Schreckenberg, Rolf, Weber, Martin, Pak, Oleg, Kojonazarov, Baktybek, Sydykov, Akylbek, Hirschhäuser, Christine, Wolf, Annemarie, Haag, Daniela, Hecker, Matthias, Fink, Ludger, Seeger, Werner, Ghofrani, Hossein A, Schermuly, Ralph T, Weißmann, Norbert, Schulz, Rainer, Rohrbach, Susanne, Li, Ling, Sommer, Natascha, Schlüter, Klaus-Dieter
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
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Spotlight Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529920/
https://ncbi.nlm.nih.gov/pubmed/30850841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz049
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