Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing

AIMS: The role of uncoupling protein 2 (UCP2) in cardiac adaptation to pressure overload remains unclear. In a classical model of left ventricular pressure overload genetic deletion of UCP2 (UCP2(−/−)) protected against cardiac hypertrophy and failure. However, in UCP2(−/−) mice increased proliferat...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Esfandiary, Azadeh, Kutsche, Hanna S, Schreckenberg, Rolf, Weber, Martin, Pak, Oleg, Kojonazarov, Baktybek, Sydykov, Akylbek, Hirschhäuser, Christine, Wolf, Annemarie, Haag, Daniela, Hecker, Matthias, Fink, Ludger, Seeger, Werner, Ghofrani, Hossein A, Schermuly, Ralph T, Weißmann, Norbert, Schulz, Rainer, Rohrbach, Susanne, Li, Ling, Sommer, Natascha, Schlüter, Klaus-Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529920/
https://ncbi.nlm.nih.gov/pubmed/30850841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz049
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