Rack1 mediates Src binding to drug transporter P-glycoprotein and modulates its activity through regulating Caveolin-1 phosphorylation in breast cancer cells

The failure of chemotherapy and the emergence of multidrug resistance (MDR) are the major obstacles for effective therapy in locally advanced and metastatic breast cancer. Overexpression of the drug transporter P-glycoprotein (P-gp) in cancer cells is one of the main causes of MDR due to its ability...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Fan, Yanling, Si, Weiyao, Ji, Wei, Wang, Zhiyong, Gao, Zicong, Tian, Ran, Song, Weijie, Zhang, He, Niu, Ruifang, Zhang, Fei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529477/
https://ncbi.nlm.nih.gov/pubmed/31113938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1633-y
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