Rack1 mediates Src binding to drug transporter P-glycoprotein and modulates its activity through regulating Caveolin-1 phosphorylation in breast cancer cells

The failure of chemotherapy and the emergence of multidrug resistance (MDR) are the major obstacles for effective therapy in locally advanced and metastatic breast cancer. Overexpression of the drug transporter P-glycoprotein (P-gp) in cancer cells is one of the main causes of MDR due to its ability...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Fan, Yanling, Si, Weiyao, Ji, Wei, Wang, Zhiyong, Gao, Zicong, Tian, Ran, Song, Weijie, Zhang, He, Niu, Ruifang, Zhang, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529477/
https://ncbi.nlm.nih.gov/pubmed/31113938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1633-y
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