Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells

BACKGROUND: Acquirement of resistance is always associated with a highly aggressive phenotype of tumor cells. Recent studies have revealed that Annexin A2 (Anxa2) is a key protein that links drug resistance and cancer metastasis. A high level of Anxa2 in cancer tissues is correlated to a highly aggr...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Fan, Yanling, Si, Weiyao, Ji, Wei, Wang, Zhiyong, Gao, Zicong, Tian, Ran, Song, Weijie, Zhang, He, Niu, Ruifang, Zhang, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530024/
https://ncbi.nlm.nih.gov/pubmed/31113450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1147-7
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