Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain

Voltage-dependent sodium (Na(V)) 1.8 channels regulate action potential generation in nociceptive neurons, identifying them as putative analgesic targets. Here, we show that Na(V)1.8 channel plasma membrane localization, retention, and stability occur through a direct interaction with the postsynapt...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Pryce, Kerri D., Powell, Rasheen, Agwa, Dalia, Evely, Katherine M., Sheehan, Garrett D., Nip, Allan, Tomasello, Danielle L., Gururaj, Sushmitha, Bhattacharjee, Arin
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529352/
https://ncbi.nlm.nih.gov/pubmed/30860870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802454RR
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