Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain

Voltage-dependent sodium (Na(V)) 1.8 channels regulate action potential generation in nociceptive neurons, identifying them as putative analgesic targets. Here, we show that Na(V)1.8 channel plasma membrane localization, retention, and stability occur through a direct interaction with the postsynapt...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Pryce, Kerri D., Powell, Rasheen, Agwa, Dalia, Evely, Katherine M., Sheehan, Garrett D., Nip, Allan, Tomasello, Danielle L., Gururaj, Sushmitha, Bhattacharjee, Arin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529352/
https://ncbi.nlm.nih.gov/pubmed/30860870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802454RR
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