Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain

Voltage-dependent sodium (Na(V)) 1.8 channels regulate action potential generation in nociceptive neurons, identifying them as putative analgesic targets. Here, we show that Na(V)1.8 channel plasma membrane localization, retention, and stability occur through a direct interaction with the postsynapt...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Pryce, Kerri D., Powell, Rasheen, Agwa, Dalia, Evely, Katherine M., Sheehan, Garrett D., Nip, Allan, Tomasello, Danielle L., Gururaj, Sushmitha, Bhattacharjee, Arin
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529352/
https://ncbi.nlm.nih.gov/pubmed/30860870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802454RR
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