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Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1
Sirtuins (SIRTs) are NAD(+)-dependent deacylases that play a key role in transcription, DNA repair, metabolism, and oxidative stress resistance. Increasing NAD(+) availability regulates endogenous SIRT activity, leading to increased resistance to oxidative stress and decreased mitochondrial reactive...
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| Pubblicato in: | FASEB J |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Federation of American Societies for Experimental Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6529338/ https://ncbi.nlm.nih.gov/pubmed/30841754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802752R |
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