Blood-derived DNA Methylation Signatures of Crohn’s Disease and Severity of Intestinal Inflammation

BACKGROUND & AIMS: Crohn’s disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicated disease, which includes stricturing (B2) with...

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Pubblicato in:Gastroenterology
Autori principali: Somineni, Hari K, Venkateswaran, Suresh, Kilaru, Varun, Marigorta, Urko M, Mo, Angela, Okou, David T, Kellermayer, Richard, Mondal, Kajari, Cobb, Dawayland, Walters, Thomas D, Griffiths, Anne, Noe, Joshua D, Crandall, Wallace V, Rosh, Joel R, Mack, David R, Heyman, Melvin B, Baker, Susan S, Stephens, Michael C, Baldassano, Robert N, Markowitz, James F, Dubinsky, Marla C, Cho, Judy, Hyams, Jeffrey S, Denson, Lee A, Gibson, Greg, Cutler, David J, Conneely, Karen N, Smith, Alicia K, Kugathasan, Subra
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529254/
https://ncbi.nlm.nih.gov/pubmed/30779925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.01.270
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