Blood-derived DNA Methylation Signatures of Crohn’s Disease and Severity of Intestinal Inflammation

BACKGROUND & AIMS: Crohn’s disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicated disease, which includes stricturing (B2) with...

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Veröffentlicht in:Gastroenterology
Hauptverfasser: Somineni, Hari K, Venkateswaran, Suresh, Kilaru, Varun, Marigorta, Urko M, Mo, Angela, Okou, David T, Kellermayer, Richard, Mondal, Kajari, Cobb, Dawayland, Walters, Thomas D, Griffiths, Anne, Noe, Joshua D, Crandall, Wallace V, Rosh, Joel R, Mack, David R, Heyman, Melvin B, Baker, Susan S, Stephens, Michael C, Baldassano, Robert N, Markowitz, James F, Dubinsky, Marla C, Cho, Judy, Hyams, Jeffrey S, Denson, Lee A, Gibson, Greg, Cutler, David J, Conneely, Karen N, Smith, Alicia K, Kugathasan, Subra
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529254/
https://ncbi.nlm.nih.gov/pubmed/30779925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.01.270
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