Translation affects mRNA stability in a codon-dependent manner in human cells

mRNA translation decodes nucleotide into amino acid sequences. However, translation has also been shown to affect mRNA stability depending on codon composition in model organisms, although universality of this mechanism remains unclear. Here, using three independent approaches to measure exogenous a...

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Publicat a:eLife
Autors principals: Wu, Qiushuang, Medina, Santiago Gerardo, Kushawah, Gopal, DeVore, Michelle Lynn, Castellano, Luciana A, Hand, Jacqelyn M, Wright, Matthew, Bazzini, Ariel Alejandro
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Chromosomes and Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529216/
https://ncbi.nlm.nih.gov/pubmed/31012849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45396
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