Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability

BACKGROUND: The regulation of messenger RNA (mRNA) stability has a profound impact on gene expression dynamics during embryogenesis. For example, in animals, maternally deposited mRNAs are degraded after fertilization to enable new developmental trajectories. Regulatory sequences in 3′ untranslated...

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Bibliographic Details
Published in:Genome Biol
Main Authors: Medina-Muñoz, Santiago Gerardo, Kushawah, Gopal, Castellano, Luciana Andrea, Diez, Michay, DeVore, Michelle Lynn, Salazar, María José Blanco, Bazzini, Ariel Alejandro
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783504/
https://ncbi.nlm.nih.gov/pubmed/33402205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02251-5
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