dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer

OBJECTIVES: Decreased deoxycytidine kinase (dCK) expression is a reported indicator of gemcitabine efficacy in pancreatic cancer, due to the impact of this kinase on gemcitabine metabolism. The transcription factor NF‐E2 p45‐related factor 2 (NRF2, also called Nfe2l2), a master regulator of redox ho...

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Bibliografiske detaljer
Udgivet i:Cell Prolif
Main Authors: Hu, Qiangsheng, Qin, Yi, Xiang, Jinfeng, Liu, Wensheng, Xu, Wenyan, Sun, Qiqing, Ji, Shunrong, Liu, Jiang, Zhang, Zheng, Ni, Quanxing, Xu, Jin, Yu, Xianjun, Zhang, Bo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528851/
https://ncbi.nlm.nih.gov/pubmed/29701272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12456
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