Potent 1,2,4-Triazino[5,6b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis

A common cause of resistance to kanamycin (KAN) in tuberculosis is overexpression of the enhanced intracellular survival (Eis) protein. Eis is an acetyltransferase that multiacetylates KAN and other aminoglycosides, rendering them unable to bind the bacterial ribosome. By high-throughput screening,...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:ACS Infect Dis
Hlavní autoři: Ngo, Huy X., Green, Keith D., Gajadeera, Chathurada S., Willby, Melisa J., Holbrook, Selina Y. L., Hou, Caixia, Garzan, Atefeh, Mayhoub, Abdelrahman S., Posey, James E., Tsodikov, Oleg. V., Garneau-Tsodikova, Sylvie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528465/
https://ncbi.nlm.nih.gov/pubmed/29601176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00074
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky