Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

The beta-site APP cleaving enzyme 1 (BACE1) is known primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the generation of Aβ peptides. Here, we provide evidence that altered BACE1 levels and activity impact the degradation of Aβ40 and Aβ42 into a com...

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發表在:Nat Commun
Main Authors: Liebsch, Filip, Kulic, Luka, Teunissen, Charlotte, Shobo, Adeola, Ulku, Irem, Engelschalt, Vivienne, Hancock, Mark A., van der Flier, Wiesje M., Kunach, Peter, Rosa-Neto, Pedro, Scheltens, Philip, Poirier, Judes, Saftig, Paul, Bateman, Randall J., Breitner, John, Hock, Christoph, Multhaup, Gerhard
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527709/
https://ncbi.nlm.nih.gov/pubmed/31110178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10152-w
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