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A tale of two drug targets: the evolutionary history of BACE1 and BACE2
The beta amyloid (APP) cleaving enzyme (BACE1) has been a drug target for Alzheimer's Disease (AD) since 1999 with lead inhibitors now entering clinical trials. In 2011, the paralog, BACE2, became a new target for type II diabetes (T2DM) having been identified as a TMEM27 secretase regulating p...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Frontiers Media S.A.
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865767/ https://ncbi.nlm.nih.gov/pubmed/24381583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00293 |
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