Nalaganje...
A tale of two drug targets: the evolutionary history of BACE1 and BACE2
The beta amyloid (APP) cleaving enzyme (BACE1) has been a drug target for Alzheimer's Disease (AD) since 1999 with lead inhibitors now entering clinical trials. In 2011, the paralog, BACE2, became a new target for type II diabetes (T2DM) having been identified as a TMEM27 secretase regulating p...
Shranjeno v:
| Main Authors: | , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2013
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865767/ https://ncbi.nlm.nih.gov/pubmed/24381583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00293 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|