Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

The beta-site APP cleaving enzyme 1 (BACE1) is known primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the generation of Aβ peptides. Here, we provide evidence that altered BACE1 levels and activity impact the degradation of Aβ40 and Aβ42 into a com...

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Publicado en:Nat Commun
Autores principales: Liebsch, Filip, Kulic, Luka, Teunissen, Charlotte, Shobo, Adeola, Ulku, Irem, Engelschalt, Vivienne, Hancock, Mark A., van der Flier, Wiesje M., Kunach, Peter, Rosa-Neto, Pedro, Scheltens, Philip, Poirier, Judes, Saftig, Paul, Bateman, Randall J., Breitner, John, Hock, Christoph, Multhaup, Gerhard
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527709/
https://ncbi.nlm.nih.gov/pubmed/31110178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10152-w
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