Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings

Recent data support that the vaginal microbiota may alter mucosal pharmacokinetics (PK) of topically delivered microbicides. Our team developed an intravaginal ring (IVR) that delivers tenofovir (TFV) (8–10 mg/day) alone or with levonorgestrel (LNG) (20 ug/day). We evaluated the effect of IVRs on th...

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Udgivet i:PLoS One
Main Authors: Thurman, Andrea Ries, Schwartz, Jill L., Ravel, Jacques, Gajer, Pawel, Marzinke, Mark A., Yousefieh, Nazita, Anderson, Sharon M., Doncel, Gustavo F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527208/
https://ncbi.nlm.nih.gov/pubmed/31107913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217229
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