Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings

Recent data support that the vaginal microbiota may alter mucosal pharmacokinetics (PK) of topically delivered microbicides. Our team developed an intravaginal ring (IVR) that delivers tenofovir (TFV) (8–10 mg/day) alone or with levonorgestrel (LNG) (20 ug/day). We evaluated the effect of IVRs on th...

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Veröffentlicht in:PLoS One
Hauptverfasser: Thurman, Andrea Ries, Schwartz, Jill L., Ravel, Jacques, Gajer, Pawel, Marzinke, Mark A., Yousefieh, Nazita, Anderson, Sharon M., Doncel, Gustavo F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527208/
https://ncbi.nlm.nih.gov/pubmed/31107913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217229
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