Pharmacokinetic and Safety Analyses of Tenofovir and Tenofovir-Emtricitabine Vaginal Tablets in Pigtailed Macaques

Vaginal rapidly disintegrating tablets (RDTs) containing tenofovir (TFV) or TFV and emtricitabine (FTC) were evaluated for safety and pharmacokinetics in pigtailed macaques. Two separate animal groups (n = 4) received TFV (10 mg) or TFV-FTC (10 mg each) RDTs, administered near the cervix. A third gr...

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Detalhes bibliográficos
Main Authors: Pereira, Lara E., Clark, Meredith R., Friend, David R., Garber, David A., McNicholl, Janet M., Hendry, R. Michael, Doncel, Gustavo F., Smith, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993262/
https://ncbi.nlm.nih.gov/pubmed/24566178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02336-13
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