Pharmacokinetic and Safety Analyses of Tenofovir and Tenofovir-Emtricitabine Vaginal Tablets in Pigtailed Macaques

Vaginal rapidly disintegrating tablets (RDTs) containing tenofovir (TFV) or TFV and emtricitabine (FTC) were evaluated for safety and pharmacokinetics in pigtailed macaques. Two separate animal groups (n = 4) received TFV (10 mg) or TFV-FTC (10 mg each) RDTs, administered near the cervix. A third gr...

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Autores principales: Pereira, Lara E., Clark, Meredith R., Friend, David R., Garber, David A., McNicholl, Janet M., Hendry, R. Michael, Doncel, Gustavo F., Smith, James M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993262/
https://ncbi.nlm.nih.gov/pubmed/24566178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02336-13
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