Complete Protection from Repeated Vaginal Simian-Human Immunodeficiency Virus Exposures in Macaques by a Topical Gel Containing Tenofovir Alone or with Emtricitabine

New-generation gels that deliver potent antiretroviral drugs against human immunodeficiency virus type 1 have renewed hopes for topical prophylaxis as a prevention strategy. Previous preclinical research with monkey models suggested that high concentrations and drug combinations are needed for high...

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Bibliographic Details
Main Authors: Parikh, Urvi M., Dobard, Charles, Sharma, Sunita, Cong, Mian-er, Jia, Hongwei, Martin, Amy, Pau, Chou-Pong, Hanson, Debra L., Guenthner, Patricia, Smith, James, Kersh, Ellen, Garcia-Lerma, J. Gerardo, Novembre, Francis J., Otten, Ron, Folks, Thomas, Heneine, Walid
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753130/
https://ncbi.nlm.nih.gov/pubmed/19656878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01073-09
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