Durable Protection from Vaginal Simian-Human Immunodeficiency Virus Infection in Macaques by Tenofovir Gel and Its Relationship to Drug Levels in Tissue

A vaginal gel containing 1% tenofovir (TFV) was found to be safe and effective in reducing HIV infection in women when used pericoitally. Because of the long intracellular half-life of TFV and high drug exposure in vaginal tissues, we hypothesized that a vaginal gel containing TFV may provide long-l...

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Bibliografiska uppgifter
Huvudupphovsmän: Dobard, Charles, Sharma, Sunita, Martin, Amy, Pau, Chou-Pong, Holder, Angela, Kuklenyik, Zsuzsanna, Lipscomb, Jonathan, Hanson, Debra L., Smith, James, Novembre, Francis J., García-Lerma, J. Gerardo, Heneine, Walid
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Vaccines and Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255839/
https://ncbi.nlm.nih.gov/pubmed/22072766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05842-11
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