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Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase

Squalene monooxygenase (SM) is a rate-limiting enzyme in cholesterol synthesis. The region comprising the first 100 amino acids, termed SM N100, represents the shortest cholesterol-responsive degron and enables SM to sense excess cholesterol in the endoplasmic reticulum (ER) membrane. Cholesterol ac...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Chua, Ngee Kiat, Hart-Smith, Gene, Brown, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527178/
https://ncbi.nlm.nih.gov/pubmed/30940729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007798
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