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Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase
Squalene monooxygenase (SM) is a rate-limiting enzyme in cholesterol synthesis. The region comprising the first 100 amino acids, termed SM N100, represents the shortest cholesterol-responsive degron and enables SM to sense excess cholesterol in the endoplasmic reticulum (ER) membrane. Cholesterol ac...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6527178/ https://ncbi.nlm.nih.gov/pubmed/30940729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007798 |
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