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A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

Cholesterol biosynthesis is a high-cost process and, therefore, tightly regulated by both transcriptional and posttranslational negative feedback mechanisms in response to the level of cellular cholesterol. Squalene monooxygenase (SM, also known as squalene epoxidase or SQLE) is a rate-limiting enzy...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Yoshioka, Hiromasa, Coates, Hudson W., Chua, Ngee Kiat, Hashimoto, Yuichi, Brown, Andrew J., Ohgane, Kenji
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132291/
https://ncbi.nlm.nih.gov/pubmed/32170014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915923117
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